| | Acorda Therapeutics Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -24.86 | -60.65 | -94.49 | -95.96 | -93.85 | -93.99 | -98.01 | -99.19 |
| | Collegium Pharmaceutical Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -16.80 | -16.02 | -17.08 | -6.53 | 28.68 | 36.42 | 117.54 | 43.25 |
| | Cumberland Pharmaceuticals Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -11.49 | -2.53 | -8.64 | -24.88 | -12.99 | -8.88 | -40.31 | -41.89 |
| | Regencell Bioscience Holdings Ltd | Drug Manufacturers - Specialty & Generic | Healthcare | -10.61 | -14.33 | 46.70 | -25.13 | -62.68 | -77.03 | -75.65 | -47.05 |
| | Sunshine Biopharma Inc Wt | Drug Manufacturers - Specialty & Generic | Healthcare | -10.06 | 27.55 | 27.55 | 100.43 | -17.47 | -68.82 | -89.68 | -76.62 |
| | cbdMD Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -8.79 | -21.59 | -32.41 | -7.41 | -4.80 | -66.54 | -97.59 | -99.56 |
| | Assertio Holdings Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -8.57 | -6.80 | 6.94 | 11.09 | -14.29 | -87.28 | -56.56 | -52.94 |
| | Canopy Growth Corp | Drug Manufacturers - Specialty & Generic | Healthcare | -8.22 | -11.62 | -0.77 | 138.16 | 73.70 | -25.82 | -83.36 | -96.26 |
| | Lucy Scientific Discovery Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -7.89 | -10.89 | -40.65 | -71.79 | -66.27 | -94.07 | -97.56 | -97.56 |
| | Clever Leaves Holdings Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -6.47 | 35.89 | -53.05 | -40.92 | 15.51 | -71.48 | -93.30 | -99.12 |
| | Durect Corp | Drug Manufacturers - Specialty & Generic | Healthcare | -6.19 | -8.62 | 26.73 | 24.71 | 99.85 | -79.54 | -74.76 | -93.69 |
| | Aquestive Therapeutics Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -6.08 | -12.22 | -24.08 | 11.55 | 83.93 | 26.64 | 173.45 | -10.43 |
| | Sonoma Pharmaceuticals Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -6.07 | -6.73 | -15.60 | -12.30 | 3.49 | -85.74 | -94.95 | -98.02 |
| | Aurora Cannabis Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -5.14 | -4.15 | -4.44 | 61.50 | 37.45 | 4.36 | -75.34 | -92.31 |
| | IM Cannabis Corp | Drug Manufacturers - Specialty & Generic | Healthcare | -4.55 | -19.53 | -3.14 | 155.86 | 57.34 | -0.76 | -92.84 | -98.54 |
| | Lifecore Biomedical Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -4.41 | -1.72 | 7.35 | -25.15 | -10.29 | 39.25 | -31.81 | -31.81 |
| | SIGA Technologies Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -3.74 | -26.50 | -19.18 | 57.34 | 62.44 | 37.37 | 13.33 | 22.63 |
| | PainReform Ltd | Drug Manufacturers - Specialty & Generic | Healthcare | -3.70 | -4.99 | -46.58 | -63.89 | -61.00 | -87.56 | -90.03 | -96.89 |
| | Supernus Pharmaceuticals Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -3.47 | -6.07 | -9.05 | 2.15 | 8.67 | -21.13 | 12.12 | -1.33 |
| | FSD Pharma Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -3.21 | -8.12 | -44.27 | -60.89 | -67.00 | -69.65 | -60.93 | -78.48 |
| | Cardiol Therapeutics Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -3.17 | 7.54 | 14.44 | 107.77 | 181.62 | 256.67 | 82.91 | -18.32 |
| | Intercure Ltd | Drug Manufacturers - Specialty & Generic | Healthcare | -3.04 | 2.24 | 30.20 | 78.21 | 198.13 | 31.28 | -46.21 | -50.92 |
| | Evoke Pharma Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.95 | -5.05 | -20.17 | -33.29 | -63.12 | -78.25 | -88.86 | -97.58 |
| | Evolus Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.89 | -4.14 | -0.16 | -7.14 | 59.38 | 21.20 | 23.07 | 43.91 |
