| | Scilex Holding Co | Drug Manufacturers - General | Healthcare | -1.78 | -13.71 | -16.47 | -50.65 | 192.26 | -6.88 | -70.71 | -86.77 |
| | Medicus Pharma Ltd Wt | Drug Manufacturers - General | Healthcare | -4.16 | -13.44 | -18.23 | -8.52 | 0.63 | -16.15 | 34.28 | 34.28 |
| | Medicus Pharma Ltd | Drug Manufacturers - General | Healthcare | 1.81 | -10.58 | -24.55 | -38.99 | -32.13 | -31.02 | -36.23 | -36.23 |
| | Scilex Holding Co Wt | Drug Manufacturers - General | Healthcare | 4.36 | -9.77 | -15.42 | -51.29 | 70.51 | -19.09 | -52.39 | -36.78 |
| | Organon & Co | Drug Manufacturers - General | Healthcare | -0.15 | -4.74 | -8.08 | -34.47 | -29.61 | -51.49 | -44.96 | -71.16 |
| | Novo Nordisk A/S ADR | Drug Manufacturers - General | Healthcare | 1.01 | -4.17 | -1.86 | -21.68 | -34.29 | -52.60 | -50.43 | -23.12 |
| | Amarin Corp Plc ADR | Drug Manufacturers - General | Healthcare | -0.22 | -3.90 | -18.73 | -10.10 | 10.05 | 48.23 | -17.86 | -42.02 |
| | Pfizer Inc | Drug Manufacturers - General | Healthcare | 0.60 | -2.55 | 1.25 | 6.67 | 8.79 | 4.82 | 1.79 | -42.19 |
| | Johnson & Johnson | Drug Manufacturers - General | Healthcare | -0.93 | -2.46 | 2.55 | 17.87 | 39.67 | 48.13 | 40.24 | 28.83 |
| | Grifols S.A. ADR | Drug Manufacturers - General | Healthcare | 1.12 | -1.31 | 5.99 | -7.39 | 4.23 | 18.40 | -12.70 | 19.96 |
| | Sanofi ADR | Drug Manufacturers - General | Healthcare | 0.40 | -1.03 | -2.76 | 1.13 | 0.67 | 4.66 | 4.41 | 15.72 |
| | GSK Plc ADR | Drug Manufacturers - General | Healthcare | 0.66 | -0.41 | 4.90 | 20.57 | 30.20 | 51.59 | 44.29 | 57.09 |
| | Biogen Inc | Drug Manufacturers - General | Healthcare | 2.88 | 0.40 | 4.09 | 22.67 | 37.59 | 18.60 | -30.55 | -38.53 |
| | AbbVie Inc | Drug Manufacturers - General | Healthcare | 1.80 | 1.57 | -2.61 | 2.69 | 24.35 | 36.86 | 58.42 | 56.77 |
| | Merck & Co Inc | Drug Manufacturers - General | Healthcare | 0.40 | 1.65 | 7.26 | 25.08 | 30.23 | 5.40 | 1.19 | 1.21 |
| | AstraZeneca Plc ADR | Drug Manufacturers - General | Healthcare | 0.83 | 1.70 | 2.66 | 19.77 | 31.50 | 44.78 | 44.57 | 44.19 |
| | Novartis AG ADR | Drug Manufacturers - General | Healthcare | 0.58 | 2.63 | 6.87 | 10.68 | 17.53 | 43.85 | 45.10 | 60.47 |
| | Amgen Inc | Drug Manufacturers - General | Healthcare | 0.91 | 3.03 | -3.70 | 15.52 | 14.88 | 29.42 | 25.07 | 35.61 |
| | Bristol Myers Squibb Co | Drug Manufacturers - General | Healthcare | 1.61 | 3.40 | 18.34 | 22.02 | 18.78 | 1.04 | 14.68 | -15.40 |
| | Gilead Sciences Inc | Drug Manufacturers - General | Healthcare | 2.32 | 3.91 | -2.31 | 9.66 | 16.11 | 40.26 | 67.30 | 59.83 |
| | Eli Lilly & Co | Drug Manufacturers - General | Healthcare | 1.38 | 4.28 | 2.08 | 42.69 | 40.99 | 42.46 | 87.34 | 206.60 |
| | MIRA Pharmaceuticals Inc | Drug Manufacturers - General | Healthcare | 1.24 | 9.40 | 16.43 | 30.40 | 33.61 | 63.00 | 39.32 | -78.03 |
