| | Scilex Holding Co | Drug Manufacturers - General | Healthcare | -2.55 | -3.03 | -26.45 | -53.38 | -55.40 | -34.76 | -87.36 | -96.89 |
| | Medicus Pharma Ltd | Drug Manufacturers - General | Healthcare | -6.78 | 10.76 | -19.71 | -50.89 | -43.88 | -72.50 | -58.49 | -58.49 |
| | Nasus Pharma Ltd | Drug Manufacturers - General | Healthcare | -6.37 | -15.25 | -23.31 | -28.57 | -42.46 | -39.39 | -39.39 | -39.39 |
| | MIRA Pharmaceuticals Inc | Drug Manufacturers - General | Healthcare | -2.03 | 2.12 | -16.90 | -13.93 | -15.14 | 3.88 | 12.62 | -83.76 |
| | Scilex Holding Co Wt | Drug Manufacturers - General | Healthcare | 20.84 | 1.87 | 21.90 | -10.29 | -64.53 | 19.14 | -62.80 | -88.79 |
| | Amarin Corp Plc ADR | Drug Manufacturers - General | Healthcare | -0.25 | 5.79 | 1.35 | -7.42 | -0.63 | 32.97 | -33.95 | -56.33 |
| | Sanofi ADR | Drug Manufacturers - General | Healthcare | 2.69 | 0.74 | 3.59 | -4.38 | -5.60 | -8.79 | 7.52 | 12.31 |
| | AbbVie Inc | Drug Manufacturers - General | Healthcare | -1.91 | -1.38 | 4.82 | -2.94 | 10.43 | 17.45 | 36.68 | 64.43 |
| | Eli Lilly & Co | Drug Manufacturers - General | Healthcare | 0.26 | -1.29 | -1.57 | -2.35 | 45.96 | 18.89 | 37.26 | 219.36 |
| | Novo Nordisk A/S ADR | Drug Manufacturers - General | Healthcare | -1.58 | -0.98 | -20.15 | -1.12 | -11.56 | -40.77 | -58.88 | -29.07 |
| | Organon & Co | Drug Manufacturers - General | Healthcare | 0.80 | 6.52 | -20.51 | 1.21 | -18.57 | -49.55 | -55.69 | -67.79 |
| | Medicus Pharma Ltd Wt | Drug Manufacturers - General | Healthcare | 15.22 | 69.55 | 41.28 | 7.67 | 55.88 | -3.64 | 76.81 | 76.81 |
| | Pfizer Inc | Drug Manufacturers - General | Healthcare | -1.86 | -2.22 | 7.01 | 9.77 | 9.76 | 11.28 | 10.97 | -24.61 |
| | Grifols S.A. ADR | Drug Manufacturers - General | Healthcare | -2.88 | 1.72 | 9.26 | 10.93 | -7.36 | 29.63 | 12.02 | -0.45 |
| | Amgen Inc | Drug Manufacturers - General | Healthcare | -1.11 | 3.25 | 14.23 | 11.21 | 29.89 | 31.61 | 40.77 | 73.15 |
| | Biogen Inc | Drug Manufacturers - General | Healthcare | -1.06 | -1.75 | 16.14 | 14.38 | 38.33 | 40.53 | -12.38 | -29.36 |
| | AstraZeneca Plc | Drug Manufacturers - General | Healthcare | -0.02 | 2.00 | 15.98 | 17.22 | 31.14 | 44.32 | 67.24 | 59.62 |
| | Gilead Sciences Inc | Drug Manufacturers - General | Healthcare | -1.06 | -0.45 | 21.73 | 18.78 | 29.83 | 44.31 | 124.45 | 98.42 |
| | Johnson & Johnson | Drug Manufacturers - General | Healthcare | 0.78 | 0.97 | 13.15 | 22.70 | 40.78 | 59.89 | 65.05 | 69.97 |
| | Novartis AG ADR | Drug Manufacturers - General | Healthcare | -0.88 | 1.70 | 14.17 | 28.76 | 31.19 | 56.87 | 67.27 | 100.97 |
| | Merck & Co Inc | Drug Manufacturers - General | Healthcare | 0.16 | 2.20 | 11.34 | 29.30 | 46.14 | 47.71 | 1.98 | 22.42 |
| | GSK Plc ADR | Drug Manufacturers - General | Healthcare | -0.54 | 3.95 | 27.70 | 31.31 | 54.93 | 73.61 | 56.90 | 90.47 |
| | Bristol Myers Squibb Co | Drug Manufacturers - General | Healthcare | 0.95 | 0.74 | 11.21 | 33.24 | 27.95 | 15.22 | 33.40 | -2.93 |
