| | Akanda Corp | Drug Manufacturers - Specialty & Generic | Healthcare | -19.14 | -44.27 | -63.94 | -88.85 | -93.23 | -94.58 | -99.77 | -99.94 |
| | Emergent Biosolutions Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -12.68 | -18.04 | -11.19 | 14.06 | 58.01 | 15.02 | 439.41 | -17.05 |
| | Pacira BioSciences Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -7.15 | -20.64 | -22.60 | -11.94 | -9.15 | -5.62 | -36.13 | -45.59 |
| | Amphastar Pharmaceuticals Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -6.34 | -6.27 | -1.18 | 12.36 | 22.76 | -28.26 | -53.15 | -10.19 |
| | BioAge Labs Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -6.15 | 54.53 | 72.63 | 278.03 | 375.88 | 338.98 | 17.48 | 17.48 |
| | cbdMD Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -5.61 | -6.48 | -15.83 | -15.13 | 4.50 | -75.06 | -83.17 | -99.06 |
| | InMed Pharmaceuticals Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -5.31 | -14.40 | -10.83 | -51.36 | -61.51 | -75.35 | -85.71 | -97.34 |
| | Aquestive Therapeutics Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -5.11 | -46.22 | -43.49 | -54.50 | -16.92 | 3.09 | 25.80 | 234.00 |
| | IM Cannabis Corp | Drug Manufacturers - Specialty & Generic | Healthcare | -4.93 | -6.25 | -11.18 | -31.47 | -56.59 | -44.44 | -17.28 | -82.69 |
| | Talphera Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -4.57 | -8.94 | -15.89 | -10.59 | 126.91 | 70.97 | 25.63 | 0.96 |
| | Alpha Teknova Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -4.39 | -7.73 | -19.39 | -31.35 | -15.91 | -53.28 | 29.82 | -36.32 |
| | Kiniksa Pharmaceuticals International Plc | Drug Manufacturers - Specialty & Generic | Healthcare | -4.15 | -9.13 | -8.74 | -2.42 | 34.99 | 101.49 | 105.98 | 162.97 |
| | BioXcel Therapeutics Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -4.02 | -4.50 | 2.14 | -28.73 | 0.53 | -65.55 | -95.26 | -99.58 |
| | Amylyx Pharmaceuticals Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -3.91 | 14.29 | 7.64 | -14.38 | 66.50 | 301.19 | -12.89 | -63.87 |
| | Esperion Therapeutics Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -3.10 | -19.95 | -17.20 | 24.21 | 176.99 | 41.63 | 11.39 | -55.29 |
| | Supernus Pharmaceuticals Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.97 | -1.78 | 6.30 | 2.01 | 49.99 | 31.19 | 76.54 | 25.40 |
| | Akebia Therapeutics Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.90 | -10.07 | -16.77 | -54.58 | -65.46 | -30.93 | -7.59 | 83.56 |
| | Shuttle Pharmaceuticals Holdings Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.63 | -17.78 | 2.07 | -61.56 | -68.51 | -92.96 | -98.32 | -99.65 |
| | Bausch Health Cos. Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.55 | -6.56 | 5.07 | 20.60 | 13.08 | -4.10 | -13.57 | -6.20 |
| | Cumberland Pharmaceuticals Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.46 | -1.45 | 60.27 | 38.37 | 36.00 | 73.72 | 144.10 | 75.65 |
| | Viatris Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.36 | 1.90 | 10.12 | 30.15 | 47.10 | 18.46 | 19.55 | 24.43 |
| | Indivior Plc | Drug Manufacturers - Specialty & Generic | Healthcare | -2.22 | -7.39 | -6.63 | 30.55 | 113.82 | 183.49 | 95.63 | 44.42 |
| | Evotec SE ADR | Drug Manufacturers - Specialty & Generic | Healthcare | -2.16 | -1.63 | 21.48 | -7.89 | -13.81 | -11.71 | -56.54 | -63.00 |
| | Tilray Brands Inc | Drug Manufacturers - Specialty & Generic | Healthcare | -1.92 | 6.35 | -11.16 | -42.20 | 63.66 | -17.71 | -53.54 | -70.03 |
