This list ranks NYSE and Nasdaq stocks by their year-to-date (YTD) price gain, the percentage change since the last close of the previous year, and shows the top 100. The YTD leaderboard is where the market's big themes of the year show up first. Penny stocks and illiquid names are excluded.
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| Symbol | Name | Industry | Sector | Exchange | Cap | Cap, mln | Last | Change | Change, % | Volume | Ytd_pct |
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| Specialty Business Services | Industrials | NASDAQ | Small | 1,149.68 |
6.51 |
0.14 | 2.2 | 2,020,391 |
914.02 |
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| Biotechnology | Healthcare | NASDAQ | Small | 701.62 |
10.71 |
0.13 | 1.23 | 71,157 |
654.23 |
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| Biotechnology | Healthcare | NASDAQ | Large | 79,388 |
207.97 |
9.12 | 4.59 | 17,513,228 |
605.22 |
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| Computer Hardware | Technology | NASDAQ | Large | 181,466 |
1,304.84 |
49.26 | 3.92 | 6,905,186 |
449.68 |
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| Biotechnology | Healthcare | NASDAQ | Mid | 6,382.37 |
14.58 |
0.8 | 5.81 | 8,773,134 |
434.07 |
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| Medical Care Facilities | Healthcare | NYSE | Small | 1,516.92 |
90.65 |
0.31 | 0.34 | 123,833 |
426.42 |
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| Waste Management | Industrials | NASDAQ | Micro | 191.02 |
4.36 |
0 | 0 | 6,373,031 |
411.92 |
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| Biotechnology | Healthcare | NASDAQ | Mid | 9,630.25 |
159.85 |
14.6 | 10.05 | 1,742,691 |
403.94 |
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| Medical Devices | Healthcare | NASDAQ | Mid | 9,506.04 |
78.02 |
5.06 | 6.94 | 1,985,506 |
378.36 |
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| Medical Devices | Healthcare | NASDAQ | Small | 497.3 |
16.08 |
0.9 | 5.93 | 543,520 |
366.09 |
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| Insurance Brokers | Financial Services | NASDAQ | Micro | 195.37 |
3.74 |
0.13 | 3.6 | 26,084 |
338.86 |
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| Biotechnology | Healthcare | NASDAQ | Mid | 8,558.18 |
8.63 |
0.82 | 10.5 | 10,482,114 |
335.86 |
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| Semiconductors | Technology | NASDAQ | Mid | 5,755.39 |
74.67 |
8.2 | 12.34 | 4,132,265 |
328.40 |
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| Biotechnology | Healthcare | NASDAQ | Mid | 5,199.21 |
15.22 |
0.23 | 1.53 | 5,085,166 |
309.14 |
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| Computer Hardware | Technology | NYSE | Mega | 296,982 |
501.96 |
34.87 | 7.47 | 6,392,156 |
304.51 |
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| Oil & Gas Equipment & Services | Energy | NASDAQ | Micro | 33.43 |
1.60 |
0.07 | 4.58 | 762,225 |
301.10 |
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| Telecom Services | Communication Services | NASDAQ | Small | 1,609.96 |
85.62 |
5.98 | 7.51 | 210,910 |
292.21 |
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| Medical Instruments & Supplies | Healthcare | NASDAQ | Mid | 3,781.52 |
53.20 |
0.54 | 1.03 | 328,419 |
287.47 |
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| Biotechnology | Healthcare | NASDAQ | Mid | 4,027.94 |
12.83 |
0.75 | 6.21 | 3,452,354 |
275.15 |
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| Diagnostics & Research | Healthcare | NASDAQ | Mid | 3,689.68 |
70.53 |
1.43 | 2.07 | 1,175,447 |
274.36 |
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| Semiconductor Equipment & Materials | Technology | NASDAQ | Mid | 3,737.67 |
58.23 |
1.96 | 3.48 | 9,259,418 |
256.15 |
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| Marine Shipping | Industrials | NASDAQ | Micro | 125.84 |
45.53 |
0.56 | 1.25 | 73,635 |
254.87 |
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| Biotechnology | Healthcare | NASDAQ | Micro | 133.02 |
3.86 |
0.23 | 6.34 | 239,616 |
238.60 |
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| Biotechnology | Healthcare | NASDAQ | Mid | 5,631.31 |
91.32 |
1.72 | 1.92 | 1,010,286 |
226.61 |
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| 100 matches |
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| Data as of Oct 27, 2026, updated intraday |
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