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Upstream Bio Inc

NASDAQ • Healthcare • Biotechnology • Quote as of 10/23/2026
Upstream Bio Inc stock price and volume chart

Company Profile

IndustryBiotechnology
SectorHealthcare
ExchangeNASDAQ
Market Capitalization151.17 mln
Float37.31 mln
Earnings Date11/05/2026

1-Year Forecast

31.14
Transformational upside

Relative Strength

3 / 100
Severely lagging

Debt / Equity

0.00
Debt-free

Pre-Tax Margin

-4,956%
Severely loss-making

ROE

-45.97
Deeply negative

Altman Z-Score

13.96
Exceptional

Business Description

Upstream Bio Inc. is a clinical-stage company focused on developing new medicines for serious inflammatory conditions, particularly those affecting the airways and lungs. Its lead treatment, verekitug, is currently being tested in clinical trials for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Founded in 2021 and based in Waltham, Massachusetts, the company is working to bring meaningful relief to patients with these difficult-to-treat conditions.

Key Fundamentals

EPS-2.88
ROE-45.97
RPS0.06
ROIC-1,362
ROA-44.34
EBITDA, mln-156
EV / EBITDA-0.18
EV / EBIT-0.18
Revenue, mln3.16
EV / Revenue8.95

Quote Details

Last 2.74
Change -0.25 (-8.36%)
Open 2.95
Volume 1,051,216
Turnover 2,880,332
Average Volume 1,202,718

Financial Ratios

Pre-Tax Profit Margin-4,956
Leverage Ratio1.04
Current Ratio27.99
Price / Book1.07
Price / Tangible Book1.07
Debt / Equity0.00
Price / Sales91.34

Financial Strength

Altman Z-Score13.96
1-Year Target Price31.14
Short Ratio7.05
Short % of Float12.67

Price Performance & Relative Strength

Period Price Performance Relative Strength
1 Week -0.72% 38 / 100   
1 Month -47% 5 / 100   
2 Months -60.74% 6 / 100   
6 Months -70.54% 6 / 100   
1 Year -87.63% 6 / 100   



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