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Upstream Bio Inc

NASDAQ • Healthcare • Biotechnology • Quote as of 05/22/2026 12:32
Upstream Bio Inc stock price and volume chart

Company Profile

IndustryBiotechnology
SectorHealthcare
ExchangeNASDAQ
Market Capitalization458.22 mln
Float35.01 mln
Earnings Date08/12/2026

Piotroski F-Score

3 / 9
Below average

Beneish M-Score

-2.02
Caution advised

1-Year Forecast

42.43
Transformational upside

Relative Strength

18 / 100
Significantly lagging

Debt / Equity

0.00
Debt-free

ROE

-35.11
Deeply negative

Business Description

Upstream Bio Inc. is a clinical-stage company focused on developing new medicines for serious inflammatory conditions, particularly those affecting the airways and lungs. Its lead treatment, verekitug, is currently being tested in clinical trials for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Founded in 2021 and based in Waltham, Massachusetts, the company is working to bring meaningful relief to patients with these difficult-to-treat conditions.

Key Fundamentals

EPS-2.90
ROE-35.11
RPS0.05
ROIC-1,360
ROA-34.10
EBITDA, mln-160
EV / EBITDA-0.76
EV / EBIT-0.76
Revenue, mln2.85
EV / Revenue39.53

Financial Strength

Altman Z-Score19.29
Piotroski F-Score 3 / 9
Beneish M-Score-2.02
1-Year Target Price42.43
Short Ratio5.29
Short % of Float9.13

Price Performance & Relative Strength

Period Price Performance Relative Strength
1 Week -7.15% 8 / 100   
1 Month -12.08% 15 / 100   
2 Months -3.54% 32 / 100   
6 Months -66.16% 6 / 100   
1 Year -5.49% 30 / 100   



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