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Spyre Therapeutics Inc

NASDAQ • Healthcare • Biotechnology • Quote as of 05/15/2026
Spyre Therapeutics Inc stock price and volume chart

Company Profile

IndustryBiotechnology
SectorHealthcare
ExchangeNASDAQ
Market Capitalization6,393.25 mln
Float80.98 mln
Earnings Date08/06/2026

Piotroski F-Score

3 / 9
Below average

1-Year Forecast

95.20
Strong upside

Relative Strength

88 / 100
Strongly outperforming

Debt / Equity

0.00
Debt-free

ROE

-32.28
Deeply negative

Dividend Yield

0.00%
No dividend

Business Description

Spyre Therapeutics is a clinical-stage biotech company based in Waltham, Massachusetts, focused on creating new treatments for inflammatory bowel disease and rheumatic conditions. The company is advancing several drug candidates that target specific proteins involved in inflammation, including standalone antibodies and combination therapies designed to address conditions such as ulcerative colitis and Crohn's disease. Formerly known as Aeglea BioTherapeutics, the company adopted its current name in November 2023 and has been operating since its founding in 2013.

Key Fundamentals

EPS-2.12
ROE-32.28
ROIC-573
ROA-28.44
EBITDA, mln-242
EV / EBITDA-24.39
EV / EBIT-24.39

Financial Strength

Piotroski F-Score 3 / 9
1-Year Target Price95.20
Short Ratio8.89
Short % of Float15.07

Price Performance & Relative Strength

Period Price Performance Relative Strength
1 Week -0.17% 65 / 100   
1 Month 7.49% 82 / 100   
2 Months 113% 98 / 100   
6 Months 220% 99 / 100   
1 Year 406% 98 / 100   



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