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Spruce Biosciences Inc

NASDAQ • Healthcare • Biotechnology • Quote as of 10/23/2026
Spruce Biosciences Inc stock price and volume chart

Company Profile

IndustryBiotechnology
SectorHealthcare
ExchangeNASDAQ
Market Capitalization129.56 mln
Float2.51 mln
Earnings Date11/16/2026

Piotroski F-Score

2 / 9
Weak

1-Year Forecast

148.00
Transformational upside

Relative Strength

82 / 100
Strongly outperforming

Debt / Equity

0.09
Debt-free

ROE

-143
Deeply negative

ROA

-103
Deeply negative

Business Description

Spruce Biosciences is a drug development company working on treatments for rare and serious medical conditions, including Sanfilippo Syndrome Type B, depression, and Congenital Adrenal Hyperplasia. Its leading programs include an enzyme-based therapy, an antidepressant compound, and a treatment for a rare hormonal disorder that currently has no cure. The company holds partnerships with Eli Lilly and Kaken Pharmaceutical to support research and bring its drugs to market in the United States and Japan. Founded in 2014, Spruce Biosciences operates out of South San Francisco, California.

Key Fundamentals

EPS-39.12
ROE-143
ROIC-1,294
ROA-103
Interest Cover-26.63
EBITDA, mln-48.67
EV / EBITDA-0.70
EV / EBIT-0.68

Quote Details

Last 45.15
Change -0.85 (-1.85%)
Open 45.80
Volume 73,815
Turnover 3,332,747
Average Volume 74,466

Financial Ratios

Leverage Ratio1.23
Current Ratio9.23
Price / Book1.60
Price / Tangible Book1.60
Debt / Equity0.09

Financial Strength

Piotroski F-Score 2 / 9
1-Year Target Price148.00
Short Ratio4.02
Short % of Float15.17

Price Performance & Relative Strength

Period Price Performance Relative Strength
1 Week 13.87% 96 / 100   
1 Month -7.89% 33 / 100   
2 Months 1.46% 69 / 100   
6 Months -16.96% 28 / 100   
1 Year -67.87% 12 / 100   



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