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Denali Therapeutics Inc

NASDAQ • Healthcare • Biotechnology • Quote as of 10/23/2026
Denali Therapeutics Inc stock price and volume chart

Company Profile

IndustryBiotechnology
SectorHealthcare
ExchangeNASDAQ
Market Capitalization2,982.75 mln
Float150 mln
Earnings Date11/11/2026

Piotroski F-Score

4 / 9
Borderline

1-Year Forecast

35.50
Transformational upside

Relative Strength

35 / 100
Underperforming

Debt / Equity

0.05
Debt-free

Pre-Tax Margin

-14,188%
Severely loss-making

ROE

-54.08
Deeply negative

Business Description

Denali Therapeutics is a biopharmaceutical company based in South San Francisco, California, focused on developing treatments for brain-related and rare metabolic diseases, including Parkinson's disease, Alzheimer's disease, frontotemporal dementia, and several lysosomal storage disorders. The company has built a broad pipeline of drug candidates that work through a variety of approaches, including enzyme replacement, gene therapy, and small molecule inhibitors. Originally founded in 2013 under the name SPR Pharma, Denali has grown into a clinical-stage company with multiple programs advancing through development, several of which are being pursued in partnership with large pharmaceutical companies.

Key Fundamentals

EPS-2.84
ROE-54.08
RPS0.02
ROIC-178
ROA-44.16
EBITDA, mln-496
EV / EBITDA-6.73
EV / EBIT-6.53
Revenue, mln3.60
EV / Revenue927

Quote Details

Last 18.41
Change -0.25 (-1.34%)
Open 18.49
Volume 1,003,056
Turnover 18,466,260
Average Volume 1,852,646

Financial Ratios

Pre-Tax Profit Margin-14,188
Leverage Ratio1.39
Current Ratio8.37
Price / Book3.95
Price / Tangible Book4.13
Debt / Equity0.05
Price / Sales1,088

Financial Strength

Altman Z-Score2.63
Piotroski F-Score 4 / 9
1-Year Target Price35.50
Short Ratio8.91
Short % of Float10.21

Price Performance & Relative Strength

Period Price Performance Relative Strength
1 Week 4.54% 87 / 100   
1 Month -10.06% 29 / 100   
2 Months -19.61% 23 / 100   
6 Months -7.35% 38 / 100   
1 Year 15.42% 74 / 100   



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