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Denali Therapeutics Inc

NASDAQ • Healthcare • Biotechnology • Quote as of 05/08/2026
Denali Therapeutics Inc stock price and volume chart

Company Profile

IndustryBiotechnology
SectorHealthcare
ExchangeNASDAQ
Market Capitalization3,200.48 mln
Float144 mln
Earnings Date07/30/2026

Piotroski F-Score

3 / 9
Below average

1-Year Forecast

35.64
Transformational upside

Relative Strength

25 / 100
Underperforming

Debt / Equity

0.04
Debt-free

ROE

-48.18
Deeply negative

Dividend Yield

0.00%
No dividend

Business Description

Denali Therapeutics is a biopharmaceutical company based in South San Francisco, California, focused on developing treatments for brain-related and rare metabolic diseases, including Parkinson's disease, Alzheimer's disease, frontotemporal dementia, and several lysosomal storage disorders. The company has built a broad pipeline of drug candidates that work through a variety of approaches, including enzyme replacement, gene therapy, and small molecule inhibitors. Originally founded in 2013 under the name SPR Pharma, Denali has grown into a clinical-stage company with multiple programs advancing through development, several of which are being pursued in partnership with large pharmaceutical companies.

Key Fundamentals

EPS-2.97
ROE-48.18
ROIC-155
ROA-42.62
EBITDA, mln-541
EV / EBITDA-4.32
EV / EBIT-4.20

Financial Strength

Piotroski F-Score 3 / 9
1-Year Target Price35.64
Short Ratio7.98
Short % of Float10.17

Price Performance & Relative Strength

Period Price Performance Relative Strength
1 Week 7.21% 86 / 100   
1 Month 1.71% 47 / 100   
2 Months -9.75% 24 / 100   
6 Months 31.77% 87 / 100   
1 Year 37.01% 73 / 100   



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