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Karyopharm Therapeutics Inc

NASDAQ • Healthcare • Biotechnology • Quote as of 10/23/2026
Karyopharm Therapeutics Inc stock price and volume chart

Company Profile

IndustryBiotechnology
SectorHealthcare
ExchangeNASDAQ
Market Capitalization12.39 mln
Float18.58 mln
Earnings Date10/29/2026

Piotroski F-Score

2 / 9
Weak

Beneish M-Score

-9.51
Highly reliable

Relative Strength

18 / 100
Significantly lagging

Pre-Tax Margin

-153%
Severely loss-making

ROE

77.63
Exceptional

Altman Z-Score

-27.4
Deeply distressed

Business Description

Karyopharm Therapeutics is a Massachusetts-based pharmaceutical company focused on developing cancer treatments that work by blocking a specific protein responsible for moving molecules out of cell nuclei. Its flagship drug, XPOVIO, is approved to treat several forms of blood cancer, including multiple myeloma and a type of aggressive lymphoma. The company is also advancing additional compounds targeting a broader range of blood and solid tumor cancers, while partnering with other pharmaceutical firms across Europe and Asia to expand the global reach of its medicines.

Key Fundamentals

EPS-14.33
ROE77.63
RPS7.55
ROIC-196
ROA-200
Interest Cover-1.67
EBITDA, mln-175
EV / EBITDA-1.60
EV / EBIT-1.60
Revenue, mln147
EV / Revenue1.91

Quote Details

Last 0.5175
Change -0.0286 (-5.24%)
Open 0.5366
Volume 1,958,855
Turnover 1,013,707
Average Volume 1,784,580

Financial Ratios

Pre-Tax Profit Margin-153
Current Ratio0.79
Price / Sales0.13

Financial Strength

Altman Z-Score-27.4
Piotroski F-Score 2 / 9
Beneish M-Score-9.51
Short Ratio4.17
Short % of Float26.84

Price Performance & Relative Strength

Period Price Performance Relative Strength
1 Week 32.66% 99 / 100   
1 Month -70.09% 1 / 100   
2 Months -93.07% 1 / 100   
6 Months -94.02% 1 / 100   
1 Year -91.57% 5 / 100   



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