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Ionis Pharmaceuticals Inc

NASDAQ • Healthcare • Biotechnology • Quote as of 05/22/2026
Ionis Pharmaceuticals Inc stock price and volume chart

Company Profile

IndustryBiotechnology
SectorHealthcare
ExchangeNASDAQ
Market Capitalization12,405 mln
Float164 mln
Earnings Date08/05/2026

Piotroski F-Score

3 / 9
Below average

Beneish M-Score

-2.86
Likely reliable

1-Year Forecast

101
Strong upside

Relative Strength

51 / 100
In line with market

Debt / Equity

4.22
Highly leveraged

ROE

-68.04
Deeply negative

Business Description

Ionis Pharmaceuticals is a California-based biotech company that develops and sells medicines targeting RNA, a key molecule that carries genetic instructions within the body. The company has several approved treatments on the market for serious conditions including spinal muscular atrophy, hereditary nerve disease, and rare disorders affecting fat metabolism. Ionis also has a broad pipeline of experimental therapies in clinical trials targeting heart disease, liver disease, neurological conditions, and other rare genetic illnesses. To support its research and commercialization efforts, the company works alongside major pharmaceutical partners including GSK, AstraZeneca, Novartis, Roche, and Biogen.

Key Fundamentals

EPS-2.01
ROE-68.04
RPS5.54
ROIC-40.04
ROA-12.42
EBITDA, mln-273
EV / EBITDA-57.80
EV / EBIT-51.89
Revenue, mln944
EV / Revenue11.86

Financial Strength

Altman Z-Score2.14
Piotroski F-Score 3 / 9
Beneish M-Score-2.86
1-Year Target Price101
Short Ratio9.12
Short % of Float13.07

Price Performance & Relative Strength

Period Price Performance Relative Strength
1 Week 1.79% 65 / 100   
1 Month 1.98% 62 / 100   
2 Months -6.25% 25 / 100   
6 Months 2.11% 44 / 100   
1 Year 126% 92 / 100   



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